Closantel-13C6 is a stable isotope-labeled form of Closantel, a halogenated salicylanilide known for its potent anti-parasitic properties. It selectively inhibits Onchocerca volvulus chitinase (OvCHT1) with an IC50 of 1.6 μM and a Ki of 468 nM, effectively disrupting the development of larvae from the L3 to L4 stage. This compound is valuable in research focused on treatments for river blindness and other helminth infections.
Closantel-13C6 is a stable isotope-labeled form of Closantel, a halogenated salicylanilide known for its potent anti-parasitic properties. It selectively inhibits Onchocerca volvulus chitinase (OvCHT1) with an IC50 of 1.6 μM and a Ki of 468 nM, effectively disrupting the development of larvae from the L3 to L4 stage. This compound is valuable in research focused on treatments for river blindness and other helminth infections.
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