Fig. 1 · Structure
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CMB-087229
SOD1 Blocker
CMB-087229 is a specific inhibitor of mutant superoxide dismutase 1 (SOD1) protein aggregation, exhibiting an IC50 of 67 nM. This compound is valuable for research into amyotrophic lateral sclerosis (ALS), providing insights into the pathogenic role of SOD1 aggregates in neurodegenerative diseases. Its application in models of ALS may aid in understanding disease mechanisms and developing potential therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1227692-67-2 |
| Applications | SOD1 Blocker |
| Formula | C10H8Cl2N2O2 |
| Molecular Weight | 259.09 |
| SMILES | O=C1C=C(COC2=CC(Cl)=CC(Cl)=C2)NN1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.