Fig. 1 · Structure
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CMS-121
Acetyl-CoA Carboxylase 1 Inhibitor
CMS-121 is a quinolone derivative that functions as an orally active inhibitor of acetyl-CoA carboxylase 1 (ACC1). It exhibits significant neuroprotective effects, providing protection to HT22 cells against ischemic and oxidative damage, with EC50 values of 7 nM and 200 nM respectively. Additionally, CMS-121 demonstrates potent anti-inflammatory, antioxidative, and renoprotective activities, making it a valuable compound for research in neuroprotection and cellular stress responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1353224-53-9 |
| Applications | Acetyl-CoA Carboxylase 1 Inhibitor |
| Formula | C20H19NO3 |
| Molecular Weight | 321.37 |
| SMILES | OC1=CC=C(C2=NC3=CC=CC=C3C(OC4CCCC4)=C2)C=C1O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.