Fig. 1 · Structure
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Cobicistat-d8
Cat. No.
A51708
CAS
2699607-48-0
CYP3A Inhibitor
Cobicistat-d8 is a deuterated analog of Cobicistat, acting as a potent and selective inhibitor of cytochrome P450 3A (CYP3A) with IC50 values ranging from 30 to 285 nM. This reagent functions primarily as a pharmacokinetic enhancer, improving the absorption and bioavailability of anti-HIV agents. Its role in modulating drug metabolism makes it a valuable tool in pharmaceutical research and drug development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2699607-48-0 |
| Applications | CYP3A Inhibitor |
| Formula | C40H45D8N7O5S2 |
| Molecular Weight | 784.07 |
| Synonyms | GS-9350-d8 |
| SMILES | CN(CC1=CSC(C(C)C)=N1)C(N[C@H](C(N[C@H](CC[C@H](CC2=CC=CC=C2)NC(OCC3=CN=CS3)=O)CC4=CC=CC=C4)=O)CCN5C([2H])(C([2H])(OC([2H])(C5([2H])[2H])[2H])[2H])[2H])=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.