Fig. 1 · Structure
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(-)-Coclaurine hydrochloride (l-Coclaurine)
nAChR Antagonist
(-)-Coclaurine hydrochloride is a tetrahydroisoquinoline alkaloid that functions as a nicotinic acetylcholine receptor (nAChR) antagonist. This compound exhibits significant biological activity in modulating nAChR-related pathways, making it valuable for research into neuropharmacology and the development of therapeutic strategies for conditions involving cholinergic signaling. Its potential applications include studies on cognitive function, addiction, and various neurological disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 3422-42-2 |
| Applications | nAChR Antagonist |
| Formula | C17H20ClNO3 |
| Molecular Weight | 321.80 |
| Synonyms | (-)-(S)-Coclaurine hydrochloride; L-Coclaurine hydrochloride; l-Coclaurine |
| SMILES | COC1=C(O)C=C2C(CCN[C@H]2CC3=CC=C(O)C=C3)=C1.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.