Fig. 1 · Structure
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COH1
Ribonucleotide Reductase Inhibitor
COH1 is a potent inhibitor of ribonucleotide reductase (RR), an essential enzyme in the de novo synthesis of nucleotides. By inhibiting RR, COH1 can impede DNA synthesis, making it a valuable tool in cancer research, as well as studies of mitochondrial disorders and neurodegenerative diseases. Its utility in these areas highlights its role in exploring therapeutic strategies that target nucleotide metabolism.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 20217-22-5 |
| Applications | Ribonucleotide Reductase Inhibitor |
| Formula | C11H10N2O3S |
| Molecular Weight | 250.27 |
| SMILES | O=C(C)NC1=NC(C2=CC(O)=C(O)C=C2)=CS1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.