COH34

Name: COH34
Brand: Adooq Bioscience
SKU: A24212
Rating: 5 (288 reviews)

Catalog No.: A24212

PARG inhibitor

COH34 is a potent and selective inhibitor of poly(ADP-ribose) glycohydrolase (PARG), with an IC50 of 0.37 nM. It binds to the catalytic domain of PARG (Kd = 0.547 μM), prolonging PARylation at sites of DNA damage and trapping DNA repair factors, thereby interfering with the DNA damage response.

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Grouped product items
Size	Price	Stock
1mg	$90.00	In stock
5mg	$270.00	In stock
10mg	$460.00	In stock
50mg	$1,380.00	In stock
Bulk Size	Bulk Discount

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Biological Activity

Description	COH34 is a potent and selective inhibitor of poly(ADP-ribose) glycohydrolase (PARG), with an IC50 of 0.37 nM. It binds to the catalytic domain of PARG (Kd = 0.547 μM), prolonging PARylation at sites of DNA damage and trapping DNA repair factors, thereby interfering with the DNA damage response.

Product Information

Catalog Num	A24212
Formula	C18H15NOS
Molecular Weight	293.38
CAS Number	906439-72-3
SMILES	CC1=CC=C(S/N=C/C2=C3C=CC=CC3=CC=C2O)C=C1
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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