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Conantokin G

Catalog No.: A67363
NMDA Receptor Antagonist
Conantokin G is a 17-amino-acid peptide that acts as a potent and selective competitive antagonist of N-methyl-D-aspartate (NMDA) receptors. It effectively inhibits NMDA-evoked currents in murine cortical neurons with an IC50 value of 480 nM. This compound exhibits neuroprotective properties, making it valuable for research in neurobiology and the study of excitotoxicity.
Conantokin G 93438-65-4 NMDA Receptor Antagonist
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5mg
$515.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionConantokin G is a 17-amino-acid peptide that acts as a potent and selective competitive antagonist of N-methyl-D-aspartate (NMDA) receptors. It effectively inhibits NMDA-evoked currents in murine cortical neurons with an IC50 value of 480 nM. This compound exhibits neuroprotective properties, making it valuable for research in neurobiology and the study of excitotoxicity.
Product Information
Catalog NumA67363
FormulaC88H138N26O44
Molecular Weight2264.19
CAS Number93438-65-4
Sequence shorteningGE-{Gla}-{Gla}-LQ-{Gla}-NQ-{Gla}-LIR-{Gla}-KSN-NH2
SMILES[C@@H](NC([C@@H](NC([C@@H](NC(CN)=O)CCC(O)=O)=O)CC(C(O)=O)C(O)=O)=O)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(N)=O)C(N)=O)=O)CO)=O)CCCCN)=O)CC(C(O)=O)C(O)=O)=O)CCCNC(=N)N)=O)[C@H](CC)C)=O)CC(C)C)=O)CC(C(O)=O)C(O)=O)=O)CCC(N)=O)=O)CC(N)=O)=O)CC(C(O)=O)C(O)=O)=O)CCC(N)=O)=O)CC(C)C)=O)CC(C(O)=O)C(O)=O
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Neuronal Signaling > NMDA Receptors