Fig. 1 · Structure

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Concanamycin E

Lysosomal Acidification Inhibitor

Concanamycin E is a potent lysosomal acidification inhibitor, exhibiting an IC50 value of 0.038 nM. This compound effectively disrupts lysosomal pH regulation, influencing cellular degradation processes and autophagy. It is widely utilized in research to study lysosomal function, cellular homeostasis, and the effects of disrupted acidification on various biological pathways.

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 144450-35-1
Applications Lysosomal Acidification Inhibitor
Formula C44H71NO14
Molecular Weight 838.03
SMILES
O=C1O[C@H]([C@@H](C)[C@@H](O)[C@@H]([C@@]2(O)C[C@@H](O[C@H]3C[C@H]([C@@H]([C@@H](C)O3)OC(N)=O)O)[C@H](C)[C@@H](/C=C/C)O2)C)[C@@H](OC)/C=C/C=C(C)/C[C@@H](C)[C@H](O)C[C@H](O)[C@H](C)/C=C(C)/C=C1\OC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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