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Form	MW
Conessine dihydrobromide This page	518.41
Conessine	356.59

Conessine dihydrobromide

H3 Receptor Antagonist

Conessine dihydrobromide is a selective antagonist of the histamine H3 receptor, demonstrating significant oral activity and the ability to penetrate the blood-brain barrier. With pKi values of 7.61 and 8.27 for rat and human H3 receptors, respectively, it has applications in studying neurological disorders. Additionally, Conessine dihydrobromide inhibits the multidrug efflux pump system in Pseudomonas aeruginosa, potentially enhancing antibiotic efficacy, and exhibits antimalarial activity. It is also relevant in research focusing on muscle atrophy.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	5913-82-6
Applications	H3 Receptor Antagonist
Formula	C₂₄H₄₂Br₂N₂
Molecular Weight	518.41
SMILES	C[C@H]1[C@]2([H])[C@]3(CN1C)[C@](CC2)([H])[C@@]4([H])[C@]([C@@]5(C(C[C@H](CC5)N(C)C)=CC4)C)([H])CC3.Br.Br

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.