Fig. 1 · Structure
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Copper(II) pyrithione
New Delhi metallo-β-lactamase 1 Inhibitor
Copper(II) pyrithione acts as an inhibitor of New Delhi metallo-β-lactamase 1 through the transmetallation of its zinc(II) cofactor with copper(II). This compound exhibits cytotoxic effects against pancreatic cancer and osteosarcoma cells, alongside notable antibacterial properties against various Gram-positive and some Gram-negative bacteria. Additionally, Copper(II) pyrithione may enhance the efficacy of β-lactam antibiotics against β-lactam-resistant bacterial strains. It is suitable for research involving pancreatic cancer, osteosarcoma, and bacterial infections.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 14915-37-8 |
| Applications | New Delhi metallo-β-lactamase 1 Inhibitor |
| Formula | C10H8CuN2O2S2 |
| Molecular Weight | 315.86 |
| SMILES | N12[O-][Cu+2]3([O-]N4C=CC=CC4=[S]3)[S]=C1C=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.