Fig. 1 · Structure
Documents & Downloads
COTC
Glyoxalase Inhibitor
COTC is a glyoxalase inhibitor derived from the bacterial metabolite found in S. griseosporeus. It demonstrates notable anticancer activity by inhibiting glyoxalase I in the presence of glutathione. COTC effectively suppresses the proliferation of HeLa cells with an IC50 value of 18 µg/mL and has been shown to reduce tumor growth and enhance survival rates in an Ehrlich murine spontaneous adenocarcinoma model, making it a valuable tool for cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 57449-30-6 |
| Applications | Glyoxalase Inhibitor |
| Formula | C11H14O6 |
| Molecular Weight | 242.23 |
| SMILES | C/C=C/C(OCC1=C[C@@H](O)[C@@H](O)[C@@H](O)C1=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.