Fig. 1 · Structure
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CP 154526 hydrochloride
CRF1 Antagonist
CP 154526 hydrochloride is a selective antagonist of corticotropin-releasing factor receptor 1 (CRF1) with a binding affinity (Ki) of 2.7 nM. This compound demonstrates high selectivity for CRF1 over CRF2, exhibiting a Ki greater than 10 μM for CRF2. CP 154526 hydrochloride is recognized for its anxiolytic properties and is utilized in research applications aimed at exploring stress-related disorders and anxiety treatment mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 257639-98-8 |
| Applications | CRF1 Antagonist |
| Formula | C23H33ClN4 |
| Molecular Weight | 400.99 |
| SMILES | CC1=C(N2C=C(C)C3=C(N(CCCC)CC)N=C(C)N=C32)C(C)=CC(C)=C1.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.