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CP-17

Name: CP-17
Brand: Adooq Bioscience
SKU: A75804
Availability: OutOfStock

Cat. No. A75804 CAS 1111233-06-7

IDH2/R140Q Inhibitor

CP-17 is a selective inhibitor of the IDH2/R140Q mutation, demonstrating an IC50 of 40.75 nM. It exhibits over 55-fold selectivity against wild-type IDH2, effectively reducing D-2-HG levels in TF-1 cells harboring the IDH2/R140Q mutation. Additionally, CP-17 effectively reverses the cellular differentiation blockade associated with the R140Q mutation, making it a valuable tool for research in acute myeloid leukemia (AML).

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1111233-06-7
Applications	IDH2/R140Q Inhibitor
Formula	C₂₅H₂₅ClN₄O₂
Molecular Weight	448.94
SMILES	O=C(NC1=CC(Cl)=CC=C1C)NC2=CC(NC(C3=CC=CC=C3)=O)=CC=C2N4CCCC4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.