CP-283097 is a selective NR2B subtype NMDA antagonist that acts competitively to inhibit [³H]CP-101,606 binding, with an IC50 of 18 nM. This compound effectively blocks NR2B-mediated currents (IC50 = 206 nM) while demonstrating minimal impact on NR2A and NR2C receptors, highlighting its specificity. CP-283097 possesses strong central nervous system permeability and has shown in vivo efficacy in preclinical models. It is suitable for research applications targeting neurological disorders associated with excessive NMDA receptor activation.
CP-283097 is a selective NR2B subtype NMDA antagonist that acts competitively to inhibit [³H]CP-101,606 binding, with an IC50 of 18 nM. This compound effectively blocks NR2B-mediated currents (IC50 = 206 nM) while demonstrating minimal impact on NR2A and NR2C receptors, highlighting its specificity. CP-283097 possesses strong central nervous system permeability and has shown in vivo efficacy in preclinical models. It is suitable for research applications targeting neurological disorders associated with excessive NMDA receptor activation.
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