Fig. 1 · Structure
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CP-601927
α4β2 nAChR Partial Agonist
CP-601927 is a selective partial agonist of the α4β2 nicotinic acetylcholine receptor (nAChR), exhibiting a Ki value of 1.2 nM and an EC50 of 2.6 μM. This compound demonstrates effective brain penetration and possesses antidepressant-like properties, making it a valuable tool in neurological research. Its modulation of nAChR activity is relevant for studies exploring neuropsychiatric disorders and the underlying mechanisms of depression.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Partial Agonist |
| CAS Number | 357425-02-6 |
| Applications | α4β2 nAChR Partial Agonist |
| Formula | C12H12F3N |
| Molecular Weight | 227.23 |
| SMILES | FC(C1=CC=C2[C@@H](C3)CNC[C@@H]3C2=C1)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.