CpG ODN 10101 is a TLR9 agonist, designed as a synthetic oligodeoxynucleotide modified with phosphate thioester. This compound activates B cells and plasmacytoid dendritic cells, leading to enhanced production of cytokines and chemokines, including interferon-α and IP-10. By modulating innate immunity and promoting Th1 adaptive responses, CpG ODN 10101 demonstrates antiviral properties and enhances vaccine immunogenicity, highlighting its potential as an immunomodulator and vaccine adjuvant in the development of therapies for chronic hepatitis C and various infectious diseases.
CpG ODN 10101 is a TLR9 agonist, designed as a synthetic oligodeoxynucleotide modified with phosphate thioester. This compound activates B cells and plasmacytoid dendritic cells, leading to enhanced production of cytokines and chemokines, including interferon-α and IP-10. By modulating innate immunity and promoting Th1 adaptive responses, CpG ODN 10101 demonstrates antiviral properties and enhances vaccine immunogenicity, highlighting its potential as an immunomodulator and vaccine adjuvant in the development of therapies for chronic hepatitis C and various infectious diseases.
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