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CPI-360 is a potent, selective,and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases.
Targets
| EZH1 | ||||
| 102.3 nM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.86 mL | 114.28 mL | 228.56 mL |
| 0.5 mM | 4.57 mL | 22.86 mL | 45.71 mL |
| 1 mM | 2.29 mL | 11.43 mL | 22.86 mL |
| 5 mM | 0.46 mL | 2.29 mL | 4.57 mL |
*The above data is based on the productmolecular weight 437.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15908 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 437.53 |
| Formula | C25H31N3O4 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1802175-06-9 |
| Synonyms | CPI360, CPI 360 |
| SMILES | CC(N1)=CC(OC)=C(CNC(C2=C(C)N([[email protected]](C)C3CCOCC3)C4=C2C=CC=C4)=O)C1=O |
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