CPPG ((RS)-CPPG) is a potent antagonist of group II and III metabotropic glutamate receptors (mGluRs). It demonstrates selective inhibition of group III mGluRs, with an IC50 of 2.2 nM, compared to an IC50 of 46.2 nM for group II mGluRs in rat cerebral cortex. Additionally, CPPG shows minimal activity at group I mGluRs. This compound is valuable for research into neuropharmacology and the modulation of glutamatergic signaling pathways.
CPPG ((RS)-CPPG) is a potent antagonist of group II and III metabotropic glutamate receptors (mGluRs). It demonstrates selective inhibition of group III mGluRs, with an IC50 of 2.2 nM, compared to an IC50 of 46.2 nM for group II mGluRs in rat cerebral cortex. Additionally, CPPG shows minimal activity at group I mGluRs. This compound is valuable for research into neuropharmacology and the modulation of glutamatergic signaling pathways.
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