Fig. 1 · Structure
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CPPG
Group II/III mGluR Antagonist
CPPG ((RS)-CPPG) is a potent antagonist of group II and III metabotropic glutamate receptors (mGluRs). It demonstrates selective inhibition of group III mGluRs, with an IC50 of 2.2 nM, compared to an IC50 of 46.2 nM for group II mGluRs in rat cerebral cortex. Additionally, CPPG shows minimal activity at group I mGluRs. This compound is valuable for research into neuropharmacology and the modulation of glutamatergic signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 183364-82-1 |
| Applications | Group II/III mGluR Antagonist |
| Formula | C11H14NO5P |
| Molecular Weight | 271.21 |
| Synonyms | (RS)-CPPG |
| SMILES | O=C(O)C(C1CC1)(N)C2=CC=C(P(O)(O)=O)C=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.