Fig. 1 · Structure
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CPS2
CDK2 Degrader
CPS2 is a highly potent and selective PROTAC that irreversibly degrades cyclin-dependent kinase 2 (CDK2) with an IC50 of 24 nM. This compound is valuable for exploring the role of CDK2 in cell cycle regulation and has applications in the study of acute myeloid leukemia. Its unique mechanism provides a powerful tool for researchers investigating targeted protein degradation in cancer therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2756741-90-7 |
| Applications | CDK2 Degrader |
| Formula | C38H42N12O10S2 |
| Molecular Weight | 890.94 |
| SMILES | O=C(N1)CCC(N2C(C3=CC=CC(NCCOCCOCCN4N=NC(COCCNS(C5=CC=C(C=C5)NC6=NN(C(N)=N6)C(C7=C(C=CS7)C)=O)(=O)=O)=C4)=C3C2=O)=O)C1=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.