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CRBN ligand-111

Ligands for E3 Ligase

CRBN ligand-111 acts as a ligand for the CRBN E3 ubiquitin ligase, facilitating targeted protein degradation through PROTAC (proteolysis-targeting chimeras) technology. This compound is vital for research focused on the modulation of ubiquitin-proteasome pathways, enabling the selective degradation of proteins involved in various cellular processes. Its application is particularly significant in studies aimed at therapeutic development, including cancer biology and neurodegenerative diseases.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	3036607-67-4
Applications	Ligands for E3 Ligase
Formula	C₁₂H₈BrClN₂O₂
Molecular Weight	327.56
SMILES	N#CC1=C(Br)C=CC(C(CC2)C(NC2=O)=O)=C1Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.