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CRBN ligand-112

Ligands for E3 Ligase

CRBN ligand-112 is a selective ligand for the CRBN-type E3 ubiquitin ligase, serving as a critical component in the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the ubiquitination and subsequent degradation of target proteins, offering a powerful tool for investigating cellular protein turnover and modulation. Its application in research spans various fields, including cancer therapy and targeted protein degradation studies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	3036607-49-2
Applications	Ligands for E3 Ligase
Formula	C₁₂H₁₁BrClNO₃
Molecular Weight	332.58
SMILES	O=C(C(C1=CC=C(Br)C(OC)=C1Cl)CC2)NC2=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.