Fig. 1 · Structure
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CRBN ligand-148
Ligands for E3 Ligase
CRBN ligand-148 is an E3 ubiquitin ligase ligand specifically targeting cereblon (CRBN). This compound facilitates the development of proteolysis-targeting chimeras (PROTACs) by promoting the ubiquitination and subsequent degradation of target proteins. Its biological activity is leveraged in research focused on targeted protein degradation and the modulation of cellular pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 3036607-19-6 |
| Applications | Ligands for E3 Ligase |
| Formula | C11H8BrCl2NO2 |
| Molecular Weight | 337.00 |
| SMILES | O=C(C(C1=C(Cl)C=C(Br)C=C1Cl)CC2)NC2=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.