CRBN ligand-16

Catalog No.: A81032
Ligands for E3 Ligase
CRBN ligand-16 is a ligand for the E3 ubiquitin ligase CRBN, enabling targeted protein degradation through the formation of PROTAC molecules. This compound facilitates the ubiquitination and subsequent proteasomal degradation of specific proteins, offering valuable applications in drug development and disease research. Its utility in creating bifunctional degradation agents makes it a crucial tool for studies involving protein modulation and therapeutic interventions.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Nature Volume 622 Issue 7982 (2023)
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Biological Activity
DescriptionCRBN ligand-16 is a ligand for the E3 ubiquitin ligase CRBN, enabling targeted protein degradation through the formation of PROTAC molecules. This compound facilitates the ubiquitination and subsequent proteasomal degradation of specific proteins, offering valuable applications in drug development and disease research. Its utility in creating bifunctional degradation agents makes it a crucial tool for studies involving protein modulation and therapeutic interventions.
Product Information
Catalog NumA81032
FormulaC12H12BrNO2
Molecular Weight282.13
CAS Number3050687-81-2
SMILESBrC1=CC=CC(C2CCC(NC2=O)=O)=C1C
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