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CRBN ligand-181

Ligands for E3 Ligase

CRBN ligand-181 is an E3 ubiquitin ligase ligand designed to engage the cereblon (CRBN) target. This compound serves as a key building block for the development of proteolysis-targeting chimeras (PROTACs), enabling targeted degradation of specific proteins within cellular systems. Its application in research facilitates the study of targeted protein degradation and modulation of cellular pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	3036607-12-9
Applications	Ligands for E3 Ligase
Formula	C₁₂H₁₁BrFNO₂
Molecular Weight	300.12
SMILES	O=C(C(C1=C(C)C=C(Br)C=C1F)CC2)NC2=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.