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CRBN ligand-183

Ligands for E3 Ligase

CRBN ligand-183 is a ligand for the CRBN-type E3 ubiquitin ligase, facilitating the development of PROTACs (proteolysis-targeting chimeras). This compound enables targeted protein degradation by harnessing the cellular ubiquitin-proteasome system. It is a valuable tool for research applications in drug discovery and development, particularly in understanding protein function and regulation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	3065251-92-2
Applications	Ligands for E3 Ligase
Formula	C₁₂H₉BrN₂O₂
Molecular Weight	293.12
SMILES	O=C(C(CC1)C2=CC=C(Br)C=C2C#N)NC1=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.