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CRBN ligand-186

CRBN Ligand

CRBN ligand-186 is a potent ligand for the CRBN-type E3 ubiquitin ligase, facilitating the construction of PROTAC (proteolysis targeting chimeras). This compound is designed to promote targeted protein degradation by harnessing the ubiquitin-proteasome system. It is instrumental in research applications aimed at investigating protein interactions and elucidating cellular processes involved in metabolic regulation and disease pathogenesis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	3084710-09-5
Applications	CRBN Ligand
Formula	C₄₄H₄₈F₂N₈O₁₁S₂
Molecular Weight	967.03
SMILES	N#CC(C(NS(=O)(N(CC)C)=O)=CC=C1F)=C1OC(C=C2C3=O)=CC=C2N=CN3[C@@H]4COC5(C4)CCN(CC5)C(CN6CCC(CC6)C7=CC=C(C=C7OS(=O)(F)=O)C8CCC(NC8=O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.