Fig. 1 · Structure
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CRBN ligand-187
CRBN Ligand
CRBN ligand-187 is a potent CRBN-type E3 ubiquitin ligase ligand that plays a crucial role in the modulation of ubiquitination processes. This compound has been utilized for the synthesis of TQ-3959, facilitating research in targeted protein degradation and cellular signaling pathways. Its ability to engage the CRBN ligase offers valuable insights for studies involving protein homeostasis and therapeutic interventions in various diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2883704-28-5 |
| Applications | CRBN Ligand |
| Formula | C12H11N3O3 |
| Molecular Weight | 245.23 |
| SMILES | NC1=CC2=C(C=C1)C(C3CCC(NC3=O)=O)=NO2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.