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CRBN ligand-267

Ligand for E3 Ligase

CRBN ligand-267 is an effective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). CRBN ligand-267 is valuable in research applications aimed at understanding protein degradation pathways and developing targeted therapies through the modulation of the ubiquitin-proteasome system.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925087-83-6
Applications	Ligand for E3 Ligase
Formula	C₁₃H₁₂N₄O₂
Molecular Weight	256.27
SMILES	O=C1NC(=O)CCN1C2=CC=CC3=CC(N)=CN=C32

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.