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CRBN ligand-277

Ligand for E3 Ligase

CRBN ligand-277 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating its recruitment to target proteins. This compound is designed for use in the development of PROTACs (proteolysis-targeting chimeras), enabling targeted degradation of specific proteins within cellular systems. Its application is crucial for studies aimed at understanding proteostasis and therapeutic strategies in diseases linked to protein dysregulation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925075-78-9
Applications	Ligand for E3 Ligase
Formula	C₁₃H₁₀BrN₃O₂
Molecular Weight	320.15
SMILES	O=C1NC(=O)CCN1C2=CC(Br)=C3C=CC=NC3=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.