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CRBN ligand-290

Ligand for E3 Ligase

CRBN ligand-290 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound serves as a building block for the development of PROTACs (Proteolysis Targeting Chimeras) by enabling the conjugation of CRBN with a target protein ligand through a suitable linker. Its application is significant in studies involving targeted protein degradation, offering insights into therapeutic interventions and functional protein regulation in various biological contexts.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925100-23-6
Applications	Ligand for E3 Ligase
Formula	C₁₂H₁₂N₄O₂
Molecular Weight	244.25
SMILES	O=C1NC(=O)CCN1C=2C=C(N)C=3C=CNC3C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.