CRBN ligand-345

Catalog No.: A81044
Ligand for E3 Ligase
CRBN ligand-345 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN). This compound is utilized to facilitate the recruitment of the CRBN protein, thereby enabling targeted protein degradation through the formation of PROTACs when linked to a target protein ligand via a suitable linker. Its application is significant in investigating the dynamics of protein turnover and elucidating cellular processes involving ubiquitination.
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Adooq Products cited in reputable paper
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Biological Activity
DescriptionCRBN ligand-345 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN). This compound is utilized to facilitate the recruitment of the CRBN protein, thereby enabling targeted protein degradation through the formation of PROTACs when linked to a target protein ligand via a suitable linker. Its application is significant in investigating the dynamics of protein turnover and elucidating cellular processes involving ubiquitination.
Product Information
Catalog NumA81044
FormulaC13H12N4O2
Molecular Weight256.27
CAS Number2925095-64-1
SMILESO=C1NC(=O)CCN1C=2C=CC=3C=NC=C(N)C3C2
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