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CRBN ligand-349

Ligand for E3 Ligase

CRBN ligand-349 is an effective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand using a linker, enabling the synthesis of proteolysis-targeting chimeras (PROTACs). It is valuable for research in targeted protein degradation and potential therapeutic applications in various disease models.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925094-79-5
Applications	Ligand for E3 Ligase
Formula	C₁₁H₁₁N₅O₂
Molecular Weight	245.24
SMILES	O=C1NC(=O)CCN1C2=CC(N)=CC=3C=NNC32

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.