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CRBN ligand-441

Ligand for E3 Ligase

CRBN ligand-441 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein for targeted protein degradation applications. By connecting CRBN ligand-441 to a target protein ligand through a linker, it can be utilized to create a PROTAC (proteolysis-targeting chimera), thereby enabling selective modulation of protein levels in cellular processes. This compound is valuable in the study of protein dynamics and therapeutic development in various diseases.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925072-75-7
Applications	Ligand for E3 Ligase
Formula	C₁₃H₁₁N₃O₃
Molecular Weight	257.25
SMILES	O=CC1=CNC=2C=C(C=CC12)N3C(=O)NC(=O)CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.