CRBN ligand-474 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC). CRBN ligand-474 is valuable in studies of targeted protein degradation and ubiquitin-proteasome pathway modulation, providing insights into cellular regulation and therapeutic applications in various diseases.
CRBN ligand-474 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC). CRBN ligand-474 is valuable in studies of targeted protein degradation and ubiquitin-proteasome pathway modulation, providing insights into cellular regulation and therapeutic applications in various diseases.
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