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CRBN ligand-476

Ligand for E3 Ligase

CRBN ligand-476 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed to be conjugated to a target protein ligand through a linker, enabling the development of proteolysis-targeting chimeras (PROTACs). Its application in targeted protein degradation provides a valuable tool for research in cellular regulation and therapeutic development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925101-49-9
Applications	Ligand for E3 Ligase
Formula	C₁₄H₁₁N₃O₄
Molecular Weight	285.26
SMILES	O=C(O)C1=CN=C2C=CC(=CC2=C1)N3C(=O)NC(=O)CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.