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CRBN ligand-477

Ligand for E3 Ligase

CRBN ligand-477 is a ligand for cereblon (CRBN), an E3 ubiquitin ligase that plays a critical role in protein degradation pathways. This compound facilitates the recruitment of the CRBN protein, enabling the targeted degradation of specific proteins when linked to a target protein ligand via a suitable linker. CRBN ligand-477 is valuable in research applications involving targeted protein degradation and PROTAC development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925101-38-6
Applications	Ligand for E3 Ligase
Formula	C₁₂H₁₀N₄O₃
Molecular Weight	258.24
SMILES	O=CC1=CC=2C=NNC2C(=C1)N3C(=O)NC(=O)CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.