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CRBN ligand-483

Ligand for E3 Ligase

CRBN ligand-483 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a specific target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis targeting chimera) for targeted protein degradation studies. It serves as a valuable tool in the exploration of protein turnover and disease mechanisms related to ubiquitination pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925097-72-7
Applications	Ligand for E3 Ligase
Formula	C₁₃H₁₂BrN₃O₂
Molecular Weight	322.16
SMILES	O=C1NC(=O)CCN1C=2C=C(Br)C3=C(C=CN3C)C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.