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CRBN ligand-489

Ligand for E3 Ligase

CRBN ligand-489 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of CRBN to target proteins. This compound can be utilized in the development of PROTACs (Proteolysis Targeting Chimeras) by being linked to target protein ligands through a suitable linker. It serves as a valuable tool for research in targeted protein degradation and elucidating cellular protein regulation mechanisms.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925095-61-8
Applications	Ligand for E3 Ligase
Formula	C₁₄H₁₁N₃O₄
Molecular Weight	285.26
SMILES	O=C(O)C1=CN=C2C(C=CC=C2N3C(=O)NC(=O)CC3)=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.