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CRBN ligand-493

Ligand for E3 Ligase

CRBN ligand-493 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with target protein ligands through a linker to generate a PROTAC (proteolysis-targeting chimera), enabling targeted protein degradation. Researchers can utilize CRBN ligand-493 in studies of protein regulation and degradation pathways, as well as in the development of novel therapeutic strategies involving targeted modulation of protein levels.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925093-76-9
Applications	Ligand for E3 Ligase
Formula	C₁₄H₁₆N₄O₂
Molecular Weight	272.31
SMILES	O=C1NC(=O)CCN1C=2C=CC=C3C2C=CN3CCN

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.