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CRBN ligand-522

Ligand for E3 Ligase

CRBN ligand-522 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), serving as a tool for targeted protein degradation. It facilitates the recruitment of cereblon to specific target proteins through a linking mechanism, enabling the formation of PROTACs (proteolysis-targeting chimeras). This compound is valuable for research applications aimed at elucidating the role of targeted degradation in cellular processes and for drug discovery strategies focusing on protein modulation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925076-05-5
Applications	Ligand for E3 Ligase
Formula	C₁₄H₁₁N₃O₄
Molecular Weight	285.26
SMILES	O=C(O)C=1C=CN=C2C1C=CC=C2N3C(=O)NC(=O)CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.