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CRBN ligand-549

Ligand for E3 Ligase

CRBN ligand-549 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), which facilitates the recruitment of CRBN to target proteins. This compound can be utilized in the design and synthesis of PROTACs (proteolysis-targeting chimeras), enabling targeted degradation of specific proteins within cellular pathways. Researchers can apply CRBN ligand-549 in studies aimed at understanding protein turnover, modulation of signaling pathways, and therapeutic development for various diseases.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925102-78-7
Applications	Ligand for E3 Ligase
Formula	C₁₃H₁₀N₄O₄
Molecular Weight	286.25
SMILES	O=C(O)C1=CC=2C=NC=NC2C(=C1)N3C(=O)NC(=O)CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.