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CRBN ligand-579

Ligand for E3 Ligase

CRBN ligand-579 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific protein targets. This compound can be utilized to create proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. Its capacity to modulate protein degradation pathways makes CRBN ligand-579 valuable for studies involving targeted protein degradation and cellular signaling research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925086-12-8
Applications	Ligand for E3 Ligase
Formula	C₁₂H₁₁BrN₄O₂
Molecular Weight	323.15
SMILES	O=C1NC(=O)CCN1C=2C=CC=3C(=NN(C3Br)C)C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.