CRBN ligand-589 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker to create a proteolysis-targeting chimeric molecule (PROTAC). Its applications in chemical biology include the modulation of protein degradation pathways and the investigation of targeted protein therapy mechanisms.
CRBN ligand-589 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker to create a proteolysis-targeting chimeric molecule (PROTAC). Its applications in chemical biology include the modulation of protein degradation pathways and the investigation of targeted protein therapy mechanisms.
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