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CRBN ligand-597

Ligand for E3 Ligase

CRBN ligand-597 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound provides a strategic tool for the development of PROTACs (proteolysis-targeting chimeras) by enabling the linkage of a target protein ligand via a suitable linker. Its application is significant in studies focused on targeted protein degradation and the modulation of cellular pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925075-21-2
Applications	Ligand for E3 Ligase
Formula	C₁₂H₁₁BrN₄O₂
Molecular Weight	323.15
SMILES	O=C1NC(=O)CCN1C=2C=C(Br)C3=CN(N=C3C2)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.