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CRBN ligand-604

Ligand for E3 Ligase

CRBN ligand-604 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of cereblon for targeted protein degradation. It can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). This reagent is instrumental in research applications focused on exploring novel therapeutic strategies for modulating protein levels and identifying potential drug targets.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925072-94-0
Applications	Ligand for E3 Ligase
Formula	C₁₂H₁₃N₅O₂
Molecular Weight	259.27
SMILES	O=C1NC(=O)CCN1C=2C=C(N)C=C3C2C=NN3C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.