Fig. 1 · Structure
Documents & Downloads
CRBN ligand-617
Ligand for E3 Ligase
CRBN ligand-617 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of CRBN to target proteins. This compound can be conjugated to a ligand that binds to a specific target protein through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). CRBN ligand-617 is applicable in studies focused on targeted protein degradation and has significant potential in drug discovery and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2713620-89-2 |
| Applications | Ligand for E3 Ligase |
| Formula | C11H9BrN4O2 |
| Molecular Weight | 309.12 |
| SMILES | O=C1NC(=O)CCN1C2=CN=C3C(Br)=CC=CN32 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.