Fig. 1 · Structure
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CRBN ligand-733
Ligand for E3 Ligase
CRBN ligand-733 is a small molecule ligand targeting the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN, allowing for the targeted degradation of specific proteins when conjugated with a target protein ligand through a linker to create a PROTAC. This compound is valuable in research applications aimed at understanding protein function and developing protein degradation strategies in therapeutic contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2903425-10-3 |
| Applications | Ligand for E3 Ligase |
| Formula | C15H20ClFN4O2 |
| Molecular Weight | 342.80 |
| SMILES | Cl.O=C1NC(=O)C(NC2=CC=C(C(F)=C2)N3CCNCC3)CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.