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CRBN ligand-74

Ligands for E3 Ligase

CRBN ligand-74 is a potent ligand for the CRBN E3 ubiquitin ligase, facilitating the development of PROTAC (Proteolysis Targeting Chimeras). It serves as a valuable tool in targeted protein degradation research, enabling the selective degradation of intracellular proteins. This compound is instrumental in studying various biological processes and therapeutic applications related to protein homeostasis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	3065251-87-5
Applications	Ligands for E3 Ligase
Formula	C₁₁H₈BrF₂NO₂
Molecular Weight	304.09
SMILES	BrC(C=CC(C1C(NC(CC1)=O)=O)=C2F)=C2F

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.