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CRBN ligand-741

Ligand for E3 Ligase

CRBN ligand-741 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of cereblon, enabling the formation of proteolysis-targeting chimeras (PROTACs) when linked to a target protein ligand via a suitable linker. This compound is valuable for studies in targeted protein degradation, offering potential applications in drug development and cancer research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925087-92-7
Applications	Ligand for E3 Ligase
Formula	C₁₄H₁₃N₃O₄
Molecular Weight	287.28
SMILES	O=C(O)C1=CC=2C=CN(C2C(=C1)N3C(=O)NC(=O)CC3)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.